CERS6-DEPENDENT CERAMIDE SYNTHESIS IN HYPOTHALAMIC NEURONS PROMOTES ER/MITOCHONDRIAL STRESS AND IMPAIRS GLUCOSE HOMEOSTASIS IN OBESE MICE

CerS6-dependent ceramide synthesis in hypothalamic neurons promotes ER/mitochondrial stress and impairs glucose homeostasis in obese mice

Abstract Dysregulation of hypothalamic ceramides has been associated with disrupted neuronal pathways in control of energy and glucose homeostasis.However, the specific ceramide species promoting neuronal lipotoxicity in obesity have remained obscure.Here, we find increased expression of the C16:0 ceramide-producing ceramide synthase (CerS)6 in cul

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Optimizing Green Extraction Methods for Maximizing the Biological Potential of Dandelion, Milk Thistle, and Chamomile Seed Extracts

This study investigates the underutilized potential of agri-crops from the Asteraceae family by employing sustainable and green technologies (supercritical fluid, ultrasound, and Soxhlet extractions) to enhance the recovery of bioactive compounds.A total click here of 21 extracts from native and waste seeds of dandelion, milk thistle, and chamomile

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